Preheat oven to 375°. Line a rimmed baking sheet with parchment paper.
In a large bowl, whisk together flour, sugar, baking powder, and salt. Using a pastry blender or forks, cut in cold butter until it resembles coarse crumbs. Add cranberries, pistachios, and orange zest, stirring to combine.
In a small bowl, stir together cold cream and vanilla extract. Add cream mixture to flour mixture, stirring until mixture is evenly moist. (If dough seems dry, add more cream, 1 tablespoon at a time.) Working gently, bring mixture together with hands until a dough forms.
Turn out dough onto a lightly floured surface, and knead gently 4 to 5 times. Using a rolling pin, roll out dough to a 1-inch thickness. Using a 2½-inch round cutter, cut 13 scones from dough, rerolling scraps as necessary. Place scones 2 inches apart on prepared baking sheet. Sprinkle tops of scones with granulated sugar, if desired.
Bake until edges of scones are golden brown and a wooden pick inserted in centers comes out clean, 15 to 17 minutes. Serve warm.
Notes
Recommended Condiments: Orange Marmalade, Devon Cream Kitchen Tip: This recipe can be modified to include gluten by substituting the gluten-free flour with all-purpose flour.
Recipe by TeaTime Magazine at https://teatimemagazine.com/gluten-free-cranberry-pistachio-orange-scone-recipe/